Gleason parts and COP

A Geometric Characterization of Gleason Parts

GPR40: Good Cop, Bad Cop?

Since its deorphanization in 2003 (1,2), the fatty acid receptor GPR40 (FFAR1/FFA1) has drawn considerable attention as a potential therapeutic target for type 2 diabetes. Because fatty acids acutely amplify insulin secretion only in the presence of glucose, the discovery of a “drugable” cell surface receptor whose activation glucose-dependently enhances insulin release generated much interest ...

p53 Good Cop/Bad Cop

Activation of the p53 transcription factor in response to a variety of cellular stresses, including DNA damage and oncogene activation, initiates a program of gene expression that blocks the proliferative expansion of damaged cells. While the beneficial impact of the anticancer function of p53 is well established, several recent papers suggest that p53 activation may in some circumstances act i...

Mixing COP and OOP

We describe and justify thirteen technical properties that a component system must possess to work with object-oriented programming languages (such as Java, C++, or C#). Our components are designed for large-scale, modular construction of programs with static checking of program compositions. Jiazzi, our enhancement of Java, implements the technical properties that we describe. We use Jiazzi co...

Good Cop, Bad Cop: Forcing Middleboxes to Cooperate

The original Internet architecture offered a clean contract to endpoints: packets sent will be delivered unmodified 1 or dropped when there is congestion. The proliferation of middleboxes has broken this simple contract to the point where the service the Internet provides to endpoints is entirely unpredictable: • Reachability depends on fields in the packet header and even the payload, as firew...